Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | HTR2B | P41595 | 4/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.30 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131380 | 0.90 | IKBKB (0.35) | ALDH1A1MAPTXBP1MAPK1NTSR1 | |
| SCHEMBL7134217 | 0.85 | CES1 (0.35) | CES1ALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL5366373 | 0.83 | KDR (0.36) | KMT2AHTR2CHTR2BHTR2AFLT3 | |
| SCHEMBL7140036 | 0.83 | MYC (0.42) | CES1ALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL5358358 | 0.80 | CES1 (0.39) | CES1ALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL7135758 | 0.80 | NPC1 (0.38) | ALDH1A1MAPTXBP1MAPK1NTSR1 | |
| SCHEMBL7138946 | 0.79 | NPC1 (0.48) | ALDH1A1MAPTXBP1MAPK1NTSR1 | |
| SCHEMBL7136928 | 0.79 | KMT2A (0.37) | ALDH1A1MAPTXBP1MAPK1NTSR1 | |
| SCHEMBL7133731 | 0.79 | PTP4A3 (0.38) | ALDH1A1MAPTXBP1MAPK1NTSR1 | |
| SCHEMBL7131271 | 0.78 | ERN1 (0.38) | ALDH1A1MAPTXBP1MAPK1NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |