Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | MAX | P61244 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 3/20 | 0.38 |
| ▸ | IL6 | P05231 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134217 | 0.90 | CES1 (0.35) | MYCMAXKDM4EKMT2AALDH1A1 | |
| SCHEMBL7136928 | 0.86 | KMT2A (0.37) | KMT2AALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL7138169 | 0.85 | POLB (0.42) | KMT2AALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL7138946 | 0.84 | NPC1 (0.48) | KDM4EKMT2AALDH1A1MAPTXBP1 | |
| SCHEMBL7139425 | 0.84 | KMT2A (0.49) | KDM4EKMT2AALDH1A1MAPTXBP1 | |
| SCHEMBL7138178 | 0.83 | CES1 (0.35) | KMT2AALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL7134441 | 0.82 | MYC (0.43) | MYCMAXTNFIL6KMT2A | |
| SCHEMBL7134889 | 0.82 | DYRK1A (0.39) | KMT2AALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL7134752 | 0.82 | PLK4 (0.48) | KMT2AALDH1A1MAPTXBP1MAPK1 | |
| SCHEMBL7135758 | 0.80 | NPC1 (0.38) | KDM4EKMT2AALDH1A1MAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |