Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131374 | 0.91 | GSK3B (0.49) | LRRK2MDM2GSK3BARSIRT2 | |
| SCHEMBL7137571 | 0.88 | POLB (0.50) | LRRK2MDM2ALDH1A1MAPTSIRT2 | |
| SCHEMBL7135667 | 0.86 | LRRK2 (0.42) | LRRK2MDM2KDM1ASIRT2SIRT1 | |
| SCHEMBL7132942 | 0.86 | PTP4A3 (0.45) | ERN1MAPTKDM1ASIRT1MEN1 | |
| SCHEMBL7138173 | 0.86 | TDP1 (0.39) | LRRK2ALDH1A1MAPTSIRT2SIRT1 | |
| SCHEMBL7138224 | 0.85 | MDM2 (0.54) | LRRK2MDM2ALDH1A1MAPTCA2 | |
| SCHEMBL5357671 | 0.84 | LRRK2 (0.51) | LRRK2ERN1MDM2ALDH1A1MAPT | |
| SCHEMBL7138047 | 0.84 | LRRK2 (0.43) | LRRK2ERN1MDM2ALDH1A1MAPT | |
| SCHEMBL7134752 | 0.82 | PLK4 (0.48) | GSK3BALDH1A1MAPTSIRT2SIRT1 | |
| SCHEMBL7138260 | 0.82 | METAP1 (0.55) | LRRK2GSK3BKDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |