Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | EEF2K | O00418 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CTRC | Q99895 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137523 | 0.95 | ERBB2 (0.46) | EGFRERBB2IGF1REEF2KSRC | |
| SCHEMBL7138387 | 0.94 | EGFR (0.46) | EGFRERBB2IGF1REEF2KSRC | |
| SCHEMBL7133835 | 0.92 | ERBB2 (0.44) | EGFRERBB2IGF1REEF2KSRC | |
| SCHEMBL7137037 | 0.89 | KMT2A (0.42) | EGFRERBB2IGF1REEF2KSRC | |
| SCHEMBL7135662 | 0.87 | ERBB2 (0.41) | EGFRERBB2IGF1RCTRCPTGS2 | |
| SCHEMBL7139429 | 0.86 | ERBB2 (0.53) | EGFRERBB2IGF1REEF2KSRC | |
| SCHEMBL7133862 | 0.85 | EEF2K (0.47) | EGFREEF2KSRCGAACYP1A2 | |
| SCHEMBL7134037 | 0.85 | MAP1LC3B (0.45) | EGFRCYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL7136796 | 0.84 | TDP1 (0.37) | EGFRERBB2IGF1REEF2KSRC | |
| SCHEMBL7132027 | 0.84 | ERBB2 (0.60) | EGFRERBB2IGF1REEF2KSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |