Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136079 | 0.82 | HTR6 (0.60) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7138600 | 0.81 | HTR6 (0.65) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7136716 | 0.80 | HTR6 (0.58) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7139483 | 0.77 | HTR6 (0.60) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7142882 | 0.77 | HTR6 (0.60) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7135285 | 0.76 | HTR6 (0.59) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7142007 | 0.75 | HTR6 (0.71) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL782195 | 0.75 | HTR6 (1.00) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL7136700 | 0.75 | HTR6 (0.71) | HTR6HTR2AHTR1DHTR2CPIK3CA | |
| SCHEMBL30516397 | 0.75 | HTR6 (1.00) | HTR6HTR2AHTR1DHTR2CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |