Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | AGO2 | Q9UKV8 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138328 | 0.91 | HTR6 (0.83) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7137357 | 0.88 | HTR6 (0.78) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7138615 | 0.85 | HTR6 (0.73) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7136171 | 0.84 | HTR6 (0.71) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7135348 | 0.84 | HTR6 (0.71) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7138620 | 0.84 | HTR6 (1.00) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL30516397 | 0.82 | HTR6 (1.00) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL782195 | 0.82 | HTR6 (1.00) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7141934 | 0.80 | HTR6 (0.67) | HTR6HTR2ATSHRLMNACYP3A4 | |
| SCHEMBL7141918 | 0.80 | HTR6 (0.67) | HTR6HTR2ATSHRLMNAHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0930302-B1 | Benzosulfone derivatives | HOFFMANN LA ROCHE (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-5990105-A | POSSESS A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; TREATING OR PREVENTING PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, DEPRESSIONS, NEUROLOGICAL DISORDERS, PARKINSON'S, AMYOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0930302-A2 | Benzosulfone derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 1999-07-21 | — | — | EP | disclosed |