Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340123 | 0.89 | MCL1 (0.56) | MCL1ACMSDCA12CA1CA2 | |
| SCHEMBL5736244 | 0.85 | ALOX5 (0.62) | ALOX5ESR2ERN1BACE1 | |
| SCHEMBL23238902 | 0.79 | SERPINE1 (0.48) | MCL1ACMSDALOX5CA12CA1 | |
| SCHEMBL8434860 | 0.79 | SERPINE1 (0.50) | MCL1ACMSDCA12CA1CA2 | |
| SCHEMBL5337591 | 0.78 | MCL1 (0.60) | MCL1ACMSDCA12CA1CA2 | |
| SCHEMBL30679633 | 0.78 | TDP1 (0.43) | CA12CA9ERN1CYP1A2CYP1B1 | |
| SCHEMBL26279852 | 0.78 | CYP1A2 (0.47) | MCL1ACMSDALOX5CA12CA1 | |
| SCHEMBL25681090 | 0.78 | SERPINE1 (0.49) | MCL1ACMSDCA12CA1CA2 | |
| SCHEMBL7170990 | 0.77 | MCL1 (0.44) | MCL1ACMSDCA12CA1CA2 | |
| SCHEMBL27254523 | 0.77 | CYP1A2 (0.46) | MCL1ACMSDALOX5CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244446-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1244446-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001039773-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-07 | — | — | WO | disclosed |