Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136436 | 0.87 | HTR6 (0.58) | HTR6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7136288 | 0.85 | HTR6 (0.80) | HTR6 | |
| SCHEMBL7133537 | 0.81 | HTR6 (0.57) | HTR6ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7141435 | 0.80 | HTR6 (0.51) | HTR6ALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL7133638 | 0.80 | HTR6 (0.50) | HTR6ALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7133635 | 0.80 | HTR6 (0.50) | HTR6ALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7134457 | 0.74 | HTR6 (0.52) | HTR6 | |
| SCHEMBL13016796 | 0.73 | HTR6 (1.00) | HTR6 | |
| SCHEMBL7134508 | 0.73 | HTR6 (0.48) | HTR6 | |
| SCHEMBL13016798 | 0.73 | HTR6 (1.00) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941994-B1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6194410-B1 | ANTISEROTONINE AGENTS; NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0941994-A1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |