Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.66 |
| ▸ | SERPINE1 | P05121 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | IDH2 | P48735 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173256 | 0.87 | NOTUM (0.85) | NOTUMSERPINE1POLBIDH2LMNA | |
| SCHEMBL4334462 | 0.87 | NOTUM (0.85) | NOTUMSERPINE1POLBIDH2LMNA | |
| SCHEMBL29957216 | 0.80 | NOTUM (1.00) | NOTUMSERPINE1POLB | |
| SCHEMBL25170450 | 0.80 | NOTUM (1.00) | NOTUMSERPINE1POLB | |
| SCHEMBL7142564 | 0.80 | SERPINE1 (0.66) | NOTUMSERPINE1POLBLMNAALDH1A1 | |
| SCHEMBL20564532 | 0.77 | KDM4E (0.50) | NOTUMLMNAHTTUSP2NPSR1 | |
| SCHEMBL31111336 | 0.77 | KDM4E (0.50) | NOTUMLMNAHTTUSP2NPSR1 | |
| SCHEMBL5801322 | 0.76 | NOTUM (0.70) | NOTUMSERPINE1POLBLMNATSHR | |
| SCHEMBL31381163 | 0.76 | NOTUM (0.70) | NOTUMSERPINE1POLBLMNATSHR | |
| SCHEMBL7087663 | 0.76 | SERPINE1 (0.89) | NOTUMSERPINE1POLBLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080060-A1 | SUBSTITUTED PIPERAZINE ANTITHROMBOTIC PAI-1 INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |