Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31310571 | 0.88 | NPC1 (0.44) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235905 | 0.88 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235953 | 0.88 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL233200 | 0.88 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235012 | 0.88 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235949 | 0.88 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL5616072 | 0.85 | NPC1 (0.43) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL27955852 | 0.79 | KMT2A (0.39) | NPC1JAK2RAB9APAX8SCN5A | |
| SCHEMBL6424475 | 0.73 | NPC1 (0.68) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL11344801 | 0.73 | NPC1 (0.68) | NPC1JAK2RAB9APAX8ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025188-B1 | LUBRICATING COMPOSITION COMPRISING A FRICTION REDUCING ADDITIVE PACKAGE AND GREASES | SHELL INT RESEARCH (NL) | 2003-07-09 | — | — | EP | disclosed |
| EP-1025188-A1 | LUBRICATING COMPOSITION COMPRISING A FRICTION REDUCING ADDITIVE PACKAGE AND GREASES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 2000-08-09 | — | — | EP | disclosed |
| US-6022835-A | Lubricating composition | SHELL OIL COMPANY (US) | 2000-02-08 | — | — | US | disclosed |
| WO-1999020719-A1 | LUBRICATING COMPOSITION COMPRISING A FRICTION REDUCING ADDITIVE PACKAGE AND GREASES | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1999-04-29 | — | — | WO | disclosed |