Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31310571 | 0.85 | NPC1 (0.44) | NPC1JAK2RAB9APAX8SCN5A | |
| SCHEMBL7140261 | 0.85 | NPC1 (0.44) | NPC1JAK2RAB9APAX8SCN5A | |
| SCHEMBL27955852 | 0.77 | KMT2A (0.39) | NPC1JAK2RAB9APAX8SCN5A | |
| SCHEMBL235949 | 0.76 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235953 | 0.76 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235905 | 0.76 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL233200 | 0.76 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL235012 | 0.76 | NPC1 (0.47) | NPC1JAK2RAB9APAX8ICMT | |
| SCHEMBL17765359 | 0.72 | NR1H2 (0.44) | SIGMAR1LMNAKMT2AMEN1CHRM2 | |
| SCHEMBL17765360 | 0.72 | NR1H2 (0.44) | SIGMAR1LMNAKMT2AMEN1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007136635-A1 | ENHANCEMENT OF RADIATION THERAPY AND/OR CHEMOTHERAPY WITH ACID CERAMIDASE MODULATORS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2007-11-29 | — | — | WO | disclosed |