Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.79 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138531 | 0.90 | HTR6 (0.64) | HTR6HTR2BKCNH2 | |
| SCHEMBL12427005 | 0.88 | HTR6 (1.00) | HTR6 | |
| SCHEMBL7133499 | 0.88 | HTR6 (0.79) | HTR6HTR2BKCNH2 | |
| SCHEMBL7140144 | 0.88 | HTR6 (0.79) | HTR6HTR2BKCNH2 | |
| SCHEMBL7138505 | 0.86 | HTR6 (0.61) | HTR6HTR2BKCNH2 | |
| SCHEMBL7133630 | 0.85 | HTR6 (0.60) | HTR6HTR2BKCNH2 | |
| SCHEMBL7139046 | 0.83 | HTR6 (0.66) | HTR6HTR2BKCNH2 | |
| SCHEMBL7136536 | 0.82 | HTR6 (0.78) | HTR6HTR2BKCNH2 | |
| SCHEMBL12427305 | 0.82 | HTR6 (0.80) | HTR6 | |
| SCHEMBL7137088 | 0.82 | HTR6 (0.70) | HTR6HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941994-B1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6194410-B1 | ANTISEROTONINE AGENTS; NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0941994-A1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |