Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 6/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138246 | 0.88 | MDM2 (0.42) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5362861 | 0.88 | MEN1 (0.46) | MDM2TGM2 | |
| SCHEMBL5365128 | 0.86 | LRRK2 (0.51) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5362198 | 0.86 | LRRK2 (0.45) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7131400 | 0.85 | MEN1 (0.42) | MDM2RETTGM2 | |
| SCHEMBL7134833 | 0.83 | MDM2 (0.43) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7134022 | 0.82 | LRRK2 (0.48) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL5367152 | 0.82 | LRRK2 (0.48) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7134020 | 0.81 | LRRK2 (0.49) | MDM2LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7138309 | 0.80 | MEN1 (0.51) | MDM2LRRK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |