Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139244 | 0.90 | MEN1 (0.51) | MEN1KMT2ARETPDGFRBFLT3 | |
| SCHEMBL7132935 | 0.84 | MEN1 (0.56) | MEN1KMT2ARETPDGFRBFLT3 | |
| SCHEMBL7134045 | 0.82 | KMT2A (0.42) | MEN1KMT2ARETPDGFRBFLT3 | |
| SCHEMBL7134014 | 0.81 | RET (0.48) | MEN1KMT2ARETPDGFRBMDM2 | |
| SCHEMBL7140872 | 0.80 | MDM2 (0.51) | RETMDM2LRRK2 | |
| SCHEMBL5369354 | 0.79 | MAP3K7 (0.54) | MEN1KMT2ARETFLT3MDM2 | |
| SCHEMBL5369742 | 0.79 | MAP3K7 (0.45) | MEN1KMT2ARETFLT3MDM2 | |
| SCHEMBL5359703 | 0.79 | RET (0.37) | MEN1KMT2ARETPDGFRBFLT3 | |
| SCHEMBL7138246 | 0.78 | MDM2 (0.42) | PDGFRBMDM2PDPK1MAPTKDR | |
| SCHEMBL5362861 | 0.78 | MEN1 (0.46) | MEN1KMT2APDGFRBFLT3MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |