Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413398 | 1.00 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL7146717 | 0.82 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL5413396 | 0.67 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL5413395 | 0.67 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL7148484 | 0.65 | NPC1 (0.49) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL13256444 | 0.64 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL7141026 | 0.61 | POLB (0.54) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL7144894 | 0.61 | POLB (0.54) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4072151 | 0.61 | NPC1 (0.85) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL5145643 | 0.61 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |