SCHEMBL7140953

SCHEMBL7140953

CC(C)(C)NS(=O)(=O)c1cccc(S(=O)(=O)Cl)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.74
KDM4E B2RXH2 2/20 0.74
MAPT P10636 2/20 0.74
SMN1; SMN2 Q16637 2/20 0.74
MEN1 O00255 2/20 0.74
NPC1 O15118 1/20 0.74
LMNA P02545 1/20 0.74
HPGD P15428 1/20 0.74
RAB9A P51151 1/20 0.74
PARG Q86W56 2/20 0.53
ALDH1A1 P00352 6/20 0.47
JAK2 O60674 1/20 0.46
SIRT2 Q8IXJ6 1/20 0.44
NSD2 O96028 2/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
MAPK1 P28482 1/20 0.41
BRD4 O60885 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10016535 0.85 SMN1; SMN2 (1.00) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL7145890 0.84 LMNA (0.77) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL23345426 0.84 KMT2A (0.77) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL7141554 0.82 MAPT (0.74) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL9917388 0.82 LMNA (0.69) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL27435146 0.82 SMN1; SMN2 (0.74) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL12093538 0.80 KMT2A (0.71) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL7142646 0.79 MEN1 (0.70) KMT2AKDM4EMAPTSMN1; SMN2MEN1
Methylamine SCHEMBL7145892 0.79 SMN1; SMN2 (0.70) KMT2AKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL520205 0.79 MAPT (0.65) KMT2AKDM4EMAPTSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0964849-B1 SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY PFIZER (US) 2003-06-04 EP disclosed
EP-1270565-A1 4-Substituted furan-2-sulfonamide and its use in the preparation of sulfonyl urea derivatives PFIZER INC. (US) 2003-01-02 EP disclosed
EP-1270554-A1 Sulfonyl urea derivatives and their use in the control of interleukin-1 activity PFIZER INC. (US) 2003-01-02 EP disclosed
US-6433009-B1 TREATMENT OF AUTOIMMUNE, CARDIOVASCULAR, NERVOUS SYSTEM, GASTROINTESTINAL, RESPIRATORY SYSTEM, AND VIRAL DISORDERS; ANTIDIABETIC, ANTIARTHRITIC, ANTIINFLAMMATORY AND ANTIDEPRESSANT AGENTS PFIZER INC 2002-08-13 US disclosed
EP-1214087-A1 COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE Pfizer Products Inc. (US) 2002-06-19 EP disclosed
WO-2001019390-A1 COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS PFIZER PRODUCTS INC. (US) 2001-03-22 WO disclosed
US-6166064-A Sulfonyl urea derivatives and their use in the control of interleukin-1 activity PFIZER INC (US) 2000-12-26 US disclosed
EP-0964849-A1 SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY PFIZER INC. (US) 1999-12-22 EP disclosed
WO-1998032733-A1 SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY PFIZER INC. (US) 1998-07-30 WO disclosed