SCHEMBL7141017

SCHEMBL7141017

COc1ccc(Cl)cc1Cn1nc(-c2ccc(C(F)(F)F)cc2)oc1=O

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ABHD6 Q9BV23 1/20 0.43
NLRP3 Q96P20 2/20 0.41
MAPT P10636 1/20 0.41
NOTUM Q6P988 1/20 0.40
KCNQ3 O43525 1/20 0.39
KCNQ2 O43526 1/20 0.39
KCNQ4 P56696 1/20 0.39
KCNMA1 Q12791 1/20 0.39
KCNQ5 Q9NR82 1/20 0.39
NPSR1 Q6W5P4 3/20 0.39
KDM4E B2RXH2 2/20 0.39
XBP1 P17861 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.37
HPGD P15428 1/20 0.37
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7950929 0.92 ABHD6 (0.43) ABHD6NLRP3MAPTNOTUMKCNQ3
SCHEMBL7212915 0.90 KMT2A (0.39) ABHD6MAPTNOTUMKMT2A
SCHEMBL7213528 0.89 KMT2A (0.40) ABHD6MAPTNOTUMNPSR1KDM4E
SCHEMBL7214134 0.88 KMT2A (0.38) ABHD6MAPTNOTUMKMT2A
SCHEMBL7952869 0.87 ABHD6 (0.43) ABHD6MAPTNOTUMKCNQ3KCNQ2
SCHEMBL8058096 0.87 CETP (0.38) ABHD6NOTUMKMT2A
SCHEMBL7208554 0.87 KMT2A (0.39) ABHD6MAPTNOTUMKMT2A
SCHEMBL5755870 0.87 NR1H2 (0.41) ABHD6NLRP3NOTUMKDM4E
SCHEMBL7207878 0.86 CETP (0.37) ABHD6NOTUMKMT2A
SCHEMBL7951068 0.86 ABHD6 (0.42) ABHD6MAPTNOTUMKCNQ3KCNQ2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056754-B1 PHOSPHATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL MYERS SQUIBB CO (US) 2003-10-22 EP disclosed
EP-1056730-A4 BENZOATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL MYERS SQUIBB CO (US) 2003-01-02 EP disclosed
EP-1051173-A4 DERIVATIVES OF 1,3,4-OXADIAZOLONE BRISTOL MYERS SQUIBB CO (US) 2002-07-31 EP disclosed
EP-1150978-A4 CARBAMATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL MYERS SQUIBB CO (US) 2002-06-12 EP disclosed
EP-1056754-A4 PHOSPHATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL MYERS SQUIBB CO (US) 2002-03-06 EP disclosed
EP-1150978-A1 CARBAMATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL-MYERS SQUIBB COMPANY (US) 2001-11-07 EP disclosed
US-6297241-B1 TREATMENT OF DISORDERS WHICH ARE RESPONSIVE TO THE OPENING OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS. BRISTOL-MYERS SQUIBB COMPANY 2001-10-02 US disclosed
US-6271249-B1 Diphenyl imidazoles as potassium channel modulators BRISTOL-MYERS SQUIBB COMPANY 2001-08-07 US disclosed
US-6162817-A Carbamate derivatives of diaryl 1,3,4-oxadiazolone BRISTOL-MYERS SQUIBB COMPANY (US) 2000-12-19 US disclosed
EP-1056754-A1 PHOSPHATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE Bristol-Myers Squibb Company (US) 2000-12-06 EP disclosed
WO-2000044745-A1 CARBAMATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL-MYERS SQUIBB COMPANY (US) 2000-08-03 WO disclosed
US-6077861-A MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE BRISTOL-MYERS SQUIBB COMPANY (US) 2000-06-20 US disclosed
US-6034113-A ANTIISCHEMIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-03-07 US disclosed
US-5977150-A Amino acid derivatives of diaryl 1,3,4-oxadiazolone BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-02 US disclosed
US-5948802-A Benzoate derivatives of diaryl 1,3,4-oxadiazolone BRISTOL-MYERS SQUIBB COMPANY (US) 1999-09-07 US disclosed
US-5939405-A Phosphate derivatives of diaryl 1,3,4-oxadiazolone BRISTOL-MYERS SQUIBB COMPANY (US) 1999-08-17 US disclosed
WO-1999038510-A1 DERIVATIVES OF 1,3,4-OXADIAZOLONE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-08-05 WO disclosed
WO-1999038873-A1 PHOSPHATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-08-05 WO disclosed
WO-1999038854-A1 BENZOATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-08-05 WO disclosed
US-5869509-A TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-02-09 US disclosed