Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107856 | 0.83 | ALOX5AP (0.60) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL9212984 | 0.76 | ALOX5AP (0.51) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL1811551 | 0.76 | ALOX5AP (0.60) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL9043810 | 0.75 | ALOX5AP (0.47) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2589634 | 0.73 | ALOX5AP (0.51) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL6112133 | 0.73 | ALOX5AP (0.60) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL4604394 | 0.72 | ALOX5AP (0.56) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL15264572 | 0.71 | ALOX5AP (0.57) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL9044721 | 0.70 | ALOX5AP (0.45) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL17663970 | 0.70 | PTK2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283836-A2 | NEUROPROTECTIVE AND ANTI-PROLIFERATIVE COMPOUNDS | Aegera Therapeutics Inc. (CA) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001087887-A2 | NEUROPROTECTIVE AND ANTI-PROLIFERATIVE COMPOUNDS | AEGERA THERAPEUTICS INC. (CA) | 2001-11-22 | — | — | WO | disclosed |