Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401467 | 0.82 | ECE1 (0.43) | LMNACYP2D6SMN1; SMN2ECE1 | |
| SCHEMBL7148707 | 0.81 | ECE1 (0.44) | ASAH1LMNACYP3A4CYP2D6MAPK3 | |
| SCHEMBL5412706 | 0.76 | DPP4 (0.42) | CYP3A4CYP2D6SMN1; SMN2ECE1 | |
| SCHEMBL5412700 | 0.76 | DPP4 (0.42) | CYP3A4CYP2D6SMN1; SMN2ECE1 | |
| SCHEMBL5404207 | 0.76 | ECE1 (0.47) | CYP3A4CYP2D6ECE1 | |
| SCHEMBL5401352 | 0.75 | ECE1 (0.32) | ECE1 | |
| SCHEMBL5405407 | 0.75 | ECE1 (0.32) | ECE1 | |
| SCHEMBL5416676 | 0.75 | ECE1 (0.40) | CYP2D6ECE1 | |
| SCHEMBL5416680 | 0.75 | ECE1 (0.40) | CYP2D6ECE1 | |
| SCHEMBL5410370 | 0.74 | ECE1 (0.43) | CYP2D6ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |