Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.36 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 5/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407311 | 0.84 | ECE1 (0.51) | ECE1PLA2G4APLA2G6CYP2D6 | |
| SCHEMBL7146865 | 0.84 | ECE1 (0.51) | ECE1PLA2G4APLA2G6CYP2D6 | |
| SCHEMBL5400964 | 0.84 | ECE1 (0.44) | ECE1PLA2G4APLA2G6CHRM4 | |
| SCHEMBL5404278 | 0.82 | ECE1 (0.51) | ECE1PLA2G4APLA2G6 | |
| SCHEMBL7141469 | 0.81 | ASAH1 (0.39) | ECE1ASAH1LMNACYP3A4CYP2D6 | |
| SCHEMBL5415467 | 0.80 | ECE1 (0.51) | ECE1PLA2G4APLA2G6CYP2D6 | |
| SCHEMBL5403789 | 0.80 | ECE1 (0.48) | ECE1PLA2G4APLA2G6 | |
| SCHEMBL5398705 | 0.80 | PKM (0.39) | PLA2G4APLA2G6ASAH1NAMPT | |
| SCHEMBL5407104 | 0.79 | ECE1 (0.47) | ECE1PLA2G4APLA2G6CYP2D6 | |
| SCHEMBL5407100 | 0.79 | ECE1 (0.47) | ECE1PLA2G4APLA2G6CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |