Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141534 | 1.00 | MAOB (0.53) | MAOBNFKB1LMNAMAPTMEN1 | |
| SCHEMBL7141537 | 1.00 | MAOB (0.53) | MAOBNFKB1LMNAMAPTMEN1 | |
| SCHEMBL9238440 | 0.83 | HIF1A (0.44) | MAOBHIF1ANFE2L2BACE1 | |
| SCHEMBL9236683 | 0.82 | HIF1A (0.45) | MAOBHIF1ANFE2L2BACE1 | |
| SCHEMBL9239702 | 0.78 | KDM4E (0.50) | MAOBLMNAMAPTKMT2AHIF1A | |
| SCHEMBL8954615 | 0.78 | HIF1A (0.47) | LMNAHIF1ANFE2L2BACE1 | |
| SCHEMBL8835428 | 0.77 | HIF1A (0.48) | LMNAMAPTMEN1KMT2AHIF1A | |
| SCHEMBL7206001 | 0.77 | HIF1A (0.48) | LMNAMAPTMEN1KMT2AHIF1A | |
| SCHEMBL7209021 | 0.77 | HIF1A (0.48) | LMNAMAPTMEN1KMT2AHIF1A | |
| SCHEMBL9239168 | 0.76 | HIF1A (0.43) | MAOBLMNAHIF1ANFE2L2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996439-B1 | BETA-ALKOXYACRYLATES AGAINST MALARIA | HOFFMANN LA ROCHE (CH) | 2003-01-08 | — | — | EP | disclosed |
| US-6084120-A | ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID | HOFFMANN-LA ROCHE INC. (US) | 2000-07-04 | — | — | US | disclosed |