Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADH5 | P11766 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705332 | 0.91 | ABL1 (0.41) | ABL1L3MBTL1ADH5MEN1KMT2A | |
| SCHEMBL7147242 | 0.91 | ABL1 (0.41) | ABL1L3MBTL1ADH5MEN1KMT2A | |
| SCHEMBL7143167 | 0.89 | ABL1 (0.41) | ABL1L3MBTL1MEN1KMT2AABCB1 | |
| SCHEMBL5868869 | 0.88 | ADH5 (0.41) | ABL1L3MBTL1ADH5KDM4DMAPK14 | |
| SCHEMBL7146597 | 0.88 | ADH5 (0.41) | ABL1L3MBTL1ADH5KDM4DMAPK14 | |
| SCHEMBL7139934 | 0.85 | ABL1 (0.41) | ABL1L3MBTL1ADH5KDM4DBRD4 | |
| SCHEMBL7145881 | 0.84 | ABL1 (0.39) | ABL1L3MBTL1ADH5ABCB1CYP3A4 | |
| SCHEMBL7139875 | 0.83 | ABL1 (0.41) | ABL1L3MBTL1CYP3A4KDM4DBRD4 | |
| SCHEMBL7140968 | 0.83 | ABL1 (0.38) | ABL1L3MBTL1ADH5CYP3A4ALDH1A1 | |
| SCHEMBL5868763 | 0.82 | ABL1 (0.37) | ABL1L3MBTL1ADH5KDM4DMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |