Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 13/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649023 | 0.86 | NEK1 (0.55) | NEK1NR3C1SMN1; SMN2NR3C2PGR | |
| SCHEMBL13810490 | 0.84 | NR3C1 (0.75) | NR3C1NR3C2PGR | |
| SCHEMBL29776944 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MMP2MMP9KMT2A | |
| SCHEMBL7299191 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MMP2MMP9KMT2A | |
| SCHEMBL20335103 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MMP2MMP9KMT2A | |
| SCHEMBL20335105 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MMP2MMP9KMT2A | |
| SCHEMBL7135670 | 0.83 | NR3C1 (0.47) | NR3C1SMN1; SMN2NR3C2PGR | |
| SCHEMBL7139970 | 0.83 | NR3C1 (0.47) | NR3C1SMN1; SMN2NR3C2PGR | |
| SCHEMBL7135675 | 0.83 | NR3C1 (0.47) | NR3C1SMN1; SMN2NR3C2PGR | |
| SCHEMBL4409126 | 0.82 | NR3C1 (0.64) | NR3C1SMN1; SMN2NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611756-B1 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-5955491-A | ADMINISTERING CATHEPSIN L INHIBITOR AND BONE RESORPTION INHIBITOR CONTAINING AN ALCOHOL OR ALDEHYDE DERIVATIVE, OR SALT THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |
| US-5716980-A | PROPHYLACTIC, THERAPY FOR OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| US-5639781-A | PREVENT REABSORPTION OF BONE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| US-5498728-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0611756-A2 | Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-24 | — | — | EP | disclosed |