Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143188 | 0.89 | HTR6 (0.56) | HTR6HTR2BHTTL3MBTL1 | |
| SCHEMBL7134457 | 0.88 | HTR6 (0.52) | HTR6HTR2B | |
| SCHEMBL7139046 | 0.83 | HTR6 (0.66) | HTR6HTR2B | |
| SCHEMBL7139029 | 0.82 | HTR6 (0.58) | HTR6HTR2BL3MBTL1 | |
| SCHEMBL7141437 | 0.78 | HTR6 (0.46) | HTR6HTR2B | |
| SCHEMBL7134508 | 0.78 | HTR6 (0.48) | HTR6HTR2B | |
| SCHEMBL7144384 | 0.77 | HTR6 (0.56) | HTR6HTR2B | |
| SCHEMBL7136436 | 0.76 | HTR6 (0.58) | HTR6 | |
| SCHEMBL7140819 | 0.75 | HTR6 (0.55) | HTR6HTR2B | |
| SCHEMBL7136309 | 0.74 | HTR6 (0.50) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941994-B1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6194410-B1 | ANTISEROTONINE AGENTS; NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0941994-A1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |