Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036145 | 0.87 | PKM (0.60) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL9265354 | 0.86 | PKM (0.58) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL9434943 | 0.82 | MAOB (0.58) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL78171 | 0.82 | MAOB (0.62) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL28826854 | 0.81 | PKM (0.54) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL17978677 | 0.81 | NR4A2 (0.57) | PKMMAOBNR4A2CACNA1BKDM4E | |
| Formaldehyde SCHEMBL27492762 | 0.81 | NR4A2 (0.58) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL6035274 | 0.81 | CACNA1B (0.55) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL10474017 | 0.80 | MAOB (0.60) | PKMMAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL9266052 | 0.80 | PKM (0.55) | PKMMAOBNR4A2NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322617-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024653-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-03-28 | — | — | WO | disclosed |