Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 16/20 | 1.00 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635942 | 0.89 | LTA4H (0.79) | LTA4HPTGER4 | |
| SCHEMBL28817980 | 0.87 | LTA4H (0.77) | LTA4HPTGER4AXLBACE1 | |
| SCHEMBL16517870 | 0.87 | LTA4H (0.77) | LTA4HPTGER4AXLBACE1 | |
| SCHEMBL7137211 | 0.83 | LTA4H (0.71) | LTA4HKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL10576723 | 0.83 | LTA4H (0.71) | LTA4HPTGER4KDM4EALDH1A1 | |
| SCHEMBL10576719 | 0.83 | LTA4H (0.71) | LTA4HPTGER4KDM4EALDH1A1 | |
| SCHEMBL7138655 | 0.83 | LTA4H (0.71) | LTA4HKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7137925 | 0.83 | LTA4H (0.70) | LTA4HKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL2770248 | 0.81 | LTA4H (0.67) | LTA4HALDH1A1 | |
| SCHEMBL2770247 | 0.81 | LTA4H (0.67) | LTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506876-B1 | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. | 2003-01-14 | — | — | US | disclosed |
| EP-0804427-B1 | LTA4 HYDROLASE INHIBITORS | SEARLE & CO (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1221441-A2 | LTA4 Hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-0786992-A2 | LTA 4? HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5585492-A | USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES WHICH ARE MEDIATED BY LTB4 PRODUCTION, SUCH AS PSORIASIS, ULCERATIVE COLITIS, IRRITABLE BOWEL DISEASE AND ASTHMA | G. D. SEARLE & CO. (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996010999-A2 | LTA4 HYDROLASE INHIBITOR PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |