Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 19/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749655 | 0.86 | ICAM1 (0.52) | ICAM1VCAM1KDM4EGAAMAPT | |
| SCHEMBL6747234 | 0.77 | ICAM1 (0.63) | ICAM1VCAM1 | |
| SCHEMBL6746538 | 0.75 | ICAM1 (0.59) | ICAM1VCAM1KDM4EGAAMAPT | |
| SCHEMBL6747419 | 0.73 | ICAM1 (0.53) | ICAM1VCAM1KDM4EGAAMAPT | |
| SCHEMBL6745340 | 0.73 | ICAM1 (0.46) | ICAM1KDM4EGAAMAPTHPGD | |
| SCHEMBL6747338 | 0.71 | ICAM1 (0.55) | ICAM1VCAM1KDM4EGAAMAPT | |
| SCHEMBL8321479 | 0.71 | ICAM1 (0.54) | ICAM1KDM4EGAAMAPTHPGD | |
| SCHEMBL6745635 | 0.71 | ALDH1A1 (0.51) | ICAM1KDM4EGAAMAPTHPGD | |
| SCHEMBL6747638 | 0.71 | ICAM1 (0.63) | ICAM1VCAM1 | |
| SCHEMBL6749084 | 0.71 | ICAM1 (0.66) | ICAM1VCAM1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |