Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880338 | 0.85 | DAPK1 (0.43) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6872075 | 0.83 | CYP1A2 (0.51) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6880171 | 0.82 | MAPT (0.53) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7143292 | 0.81 | NTRK1 (0.50) | MAPTKDM4ETDP1NPSR1NTRK1 | |
| SCHEMBL6879275 | 0.73 | NPSR1 (0.63) | MAPTCYP1A2CYP2C9CYP2C19TDP1 | |
| SCHEMBL6872072 | 0.72 | CYP1A2 (0.50) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6872458 | 0.70 | KMT2A (0.63) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6881285 | 0.69 | NPC1 (0.43) | MAPTKDM4ETDP1NPSR1NTRK1 | |
| SCHEMBL16670315 | 0.68 | KMT2A (0.50) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4496709 | 0.66 | ABL1 (0.49) | KDM4ECYP1A2CYP2C9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339698-A2 | PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002042280-A2 | PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | WO | disclosed |