Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 10/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135177 | 0.91 | SCN2A (0.41) | SPHK1CNR2SCN2ACNR1NPY5R | |
| SCHEMBL7145617 | 0.90 | SCN2A (0.41) | SPHK1CNR2SCN2ACNR1NPY5R | |
| SCHEMBL7140240 | 0.83 | SCN2A (0.42) | SPHK1CNR2SCN2ACNR1NPY5R | |
| SCHEMBL7143632 | 0.78 | SPHK1 (0.43) | SPHK1CNR2SCN2ACNR1NPY5R | |
| SCHEMBL7139526 | 0.75 | SCN2A (0.50) | CNR2SCN2ACNR1NPY5R | |
| SCHEMBL8108537 | 0.74 | SPHK1 (0.42) | SPHK1CNR2SCN2ACNR1 | |
| SCHEMBL7143472 | 0.73 | SCN2A (0.48) | CNR2SCN2ACNR1NPY5RADRA2C | |
| SCHEMBL8117997 | 0.73 | SCN2A (0.50) | CNR2SCN2ACNR1NPY5R | |
| SCHEMBL7142302 | 0.72 | SCN2A (0.52) | CNR2SCN2ACNR1NPY5R | |
| SCHEMBL7135182 | 0.72 | SCN2A (0.41) | SPHK1CNR2SCN2ACNR1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | claimed |
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |