Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.50 |
| ▸ | HTR2B | P41595 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140042 | 0.85 | HTR6 (0.65) | HTR6HTR2BKCNH2 | |
| SCHEMBL7138522 | 0.83 | HTR6 (0.72) | HTR6HTR2B | |
| SCHEMBL7142930 | 0.83 | HTR6 (0.58) | HTR6HTR2BALDH1A1L3MBTL1 | |
| SCHEMBL7139029 | 0.83 | HTR6 (0.58) | HTR6HTR2BALDH1A1L3MBTL1 | |
| SCHEMBL19381944 | 0.83 | HTR6 (0.71) | HTR6HTR2BKCNH2 | |
| SCHEMBL7139033 | 0.81 | HTR6 (0.55) | HTR6ALDH1A1L3MBTL1 | |
| SCHEMBL7135380 | 0.79 | HTR6 (0.51) | HTR6ALDH1A1L3MBTL1 | |
| SCHEMBL7139980 | 0.79 | HTR6 (0.54) | HTR6ALDH1A1L3MBTL1 | |
| SCHEMBL7140118 | 0.76 | HTR6 (0.48) | HTR6KCNH2 | |
| SCHEMBL7136379 | 0.76 | HTR6 (0.62) | HTR6HTR2BKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941994-B1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6194410-B1 | ANTISEROTONINE AGENTS; NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0941994-A1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |