Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143119 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL7143125 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL7143120 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL9041784 | 0.73 | CYP3A4 (0.56) | SMN1; SMN2RAB9APOLBCTRB1GAA | |
| SCHEMBL8477065 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8481499 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8478003 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8477063 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8479641 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8482001 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |