Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477063 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8478003 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8477065 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8481499 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL8479641 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL28831818 | 0.90 | AGTR2 (0.48) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL4804145 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL4804141 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL4804132 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL3825810 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APOLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942537-A | ADMINISTERING A L-TRANS PYRROLIDINE DERIVATIVE TO INHIBIT THE TRANSPORT OF L-GLUTAMATE OR L-ASPARTATE OR AN EXCITATORY AMINO ACID NEUROTRANSMITTER AWAY FROM A SYNAPSE COMPRISING CONTACTING SYNAPSE WITH PYRROLIDINE DERIVATIVE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0497895-A1 | METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006536-A1 | METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1991-05-16 | — | — | WO | disclosed |