Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5997822 | 0.91 | MAPK14 (0.74) | MAPK14MAPK11MAP4K4FAAHMAPK13 | |
| SCHEMBL1127770 | 0.89 | MAPK14 (0.71) | MAPK14MAPK11MAP4K4FAAHMAPK13 | |
| SCHEMBL5998654 | 0.87 | MAPK14 (0.87) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL13035057 | 0.86 | MAPK14 (0.82) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| Rwj-67657 SCHEMBL162010 | 0.86 | MAPK14 (1.00) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL12856400 | 0.86 | MAPK14 (1.00) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| Rwj-67657 SCHEMBL5815060 | 0.85 | MAPK14 (0.98) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL5999009 | 0.85 | MAPK14 (0.91) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7145536 | 0.84 | MAPK14 (0.89) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7141213 | 0.84 | MAPK14 (0.82) | MAPK14MAPK11MAP4K4MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028954-B1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO MCNEIL PHARM INC (US) | 2003-07-02 | — | — | EP | claimed |
| EP-1028954-A1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-08-23 | — | — | EP | claimed |
| WO-1998047892-A1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO-MCNEIL CORPORATION, INC. (US) | 1998-10-29 | — | — | WO | claimed |