Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146854 | 0.87 | PDE4D (0.43) | FYN | |
| SCHEMBL7043840 | 0.85 | PARP1 (0.43) | FYNPARP1 | |
| SCHEMBL7146568 | 0.85 | IKBKB (0.38) | FYNPARP1 | |
| SCHEMBL14888540 | 0.85 | FYN (0.46) | FYNPI4K2APARP1DHODHDYRK3 | |
| SCHEMBL7145673 | 0.85 | TLR8 (0.48) | FYNPARP1DHODH | |
| SCHEMBL7041861 | 0.84 | IKBKB (0.46) | DYRK1B | |
| SCHEMBL6876511 | 0.84 | FYN (0.37) | FYN | |
| SCHEMBL7150015 | 0.81 | KDM4E (0.49) | FYNBRAFPARP1DYRK3CCNT1 | |
| SCHEMBL7041042 | 0.80 | HPGD (0.39) | FYN | |
| SCHEMBL7144535 | 0.79 | NTRK1 (0.40) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |