Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 7/20 | 0.45 |
| ▸ | HTR1B | P28222 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141265 | 0.84 | HTR1F (0.76) | HTR1FMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL7141051 | 0.84 | HTR1F (0.71) | HTR1FLMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27498236 | 0.82 | HTR1F (0.72) | HTR1FLMNAPOLBMAPTALDH1A1 | |
| SCHEMBL7144554 | 0.81 | HTR1F (0.77) | HTR1FMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL7143303 | 0.79 | HTR1F (1.00) | HTR1FLMNAMAPTSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7138726 | 0.79 | HTR1F (0.98) | HTR1FLMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7144771 | 0.77 | HTR1F (0.83) | HTR1FLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL8598857 | 0.76 | HTR1F (0.81) | HTR1FLMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL7142217 | 0.76 | HTR1F (0.62) | HTR1FMAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL7145129 | 0.76 | HTR1F (0.62) | HTR1FMAPTSMN1; SMN2L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768301-B1 | N-(2-substituted-3-(2-aminoethyl)-1H-indol-5-yl)-amides as new 5-HT1F agonists | LILLY CO ELI (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6126932-A | INSOLUBLE POLYMER BEARING PENDANT SIDE CHAINS, SAID SIDE CHAINS EACH TERMINATING WITH THE 1-(3-(1-PYRROLIDINYL)-PROPYL)-3-ETHYLCARBODIIMIDE MOIETY. | ELI LILLY AND COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0768301-A1 | N-(2-substituted-3-(2-aminoethyl)-1H-indol-5-yl)-amides as new 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |