Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 2/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424828 | 0.90 | ITGB2 (0.39) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29960585 | 0.81 | HTR2A (0.40) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| SCHEMBL11886853 | 0.81 | AKR1B1 (0.47) | KMT2ASMN1; SMN2HTTGAA | |
| SCHEMBL7143121 | 0.80 | KMT2A (0.39) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| SCHEMBL3421953 | 0.79 | ITGB2 (0.35) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| SCHEMBL3428659 | 0.79 | KMT2A (0.36) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| SCHEMBL25871757 | 0.79 | ITGB2 (0.41) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| SCHEMBL7143699 | 0.77 | SMN1; SMN2 (0.42) | KMT2ASMN1; SMN2GAA | |
| SCHEMBL30403463 | 0.77 | ITGB2 (0.43) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 | |
| SCHEMBL5175220 | 0.76 | KMT2A (0.33) | ITGB2ICAM1ITGALKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179198-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. | 2018-06-28 | — | — | US | disclosed |
| US-9856253-B2 | Tricyclic modulators of TNF signaling | ABBVIE, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20160304517-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. | 2016-10-20 | — | — | US | disclosed |
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304517-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | TNF, TNFRSF1A, CD40 | ITGB2 3968/4885ICAM1 1123/4885ITGAL 3416/4885 |
| US-20180179198-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | TNF, TNFRSF1A, CD40 | ITGB2 3968/4885ICAM1 1123/4885ITGAL 3416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.