Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RARA | P10276 | 3/20 | 0.37 |
| ▸ | RARB | P10826 | 3/20 | 0.37 |
| ▸ | RARG | P13631 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137830 | 0.83 | RARA (0.38) | SMN1; SMN2GAAMAPTALDH1A1G6PD | |
| SCHEMBL7143121 | 0.81 | KMT2A (0.39) | SMN1; SMN2KMT2A | |
| SCHEMBL7140448 | 0.80 | RARA (0.36) | SMN1; SMN2GAAMAPTALDH1A1G6PD | |
| SCHEMBL5477166 | 0.78 | GAA (0.47) | GAAALDH1A1KMT2A | |
| SCHEMBL11886853 | 0.78 | AKR1B1 (0.47) | SMN1; SMN2GAAMAPTALDH1A1KMT2A | |
| SCHEMBL7144622 | 0.77 | ITGB2 (0.39) | SMN1; SMN2GAAKMT2A | |
| SCHEMBL3424828 | 0.77 | ITGB2 (0.39) | SMN1; SMN2GAAKMT2A | |
| SCHEMBL7141441 | 0.77 | RARA (0.34) | SMN1; SMN2GAAMAPTALDH1A1G6PD | |
| SCHEMBL5172725 | 0.74 | AKR1B1 (0.38) | SMN1; SMN2GAAMAPTALDH1A1KMT2A | |
| SCHEMBL7139418 | 0.74 | RARB (0.49) | KMT2ARARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151144-C | Benzopyrans and benzothiopyrans as RAR selective retinoid agonists | - | 2004-05-26 | — | — | CN | disclosed |
| EP-1212316-B1 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | HOFFMANN LA ROCHE (CH) | 2003-10-15 | — | — | EP | disclosed |
| US-6479670-B1 | Selective retinoid acid receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| CN-1370156-A | Benzopyrans and benzothiopyrans as RAR selective retinoid agonists | HOFFMANN LA ROCHE (CH) | 2002-09-18 | — | — | CN | disclosed |
| EP-1212316-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014360-A2 | BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2001-03-01 | — | — | WO | disclosed |