Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31397205 | 0.84 | GRM5 (0.50) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL11957019 | 0.82 | GRM5 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL21078113 | 0.82 | GRM5 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL19046612 | 0.80 | GRM5 (0.58) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL12240997 | 0.80 | GRM5 (0.55) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL6688964 | 0.80 | GRM5 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL17886619 | 0.80 | GRM5 (0.55) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL9381267 | 0.80 | GRM5 (0.55) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL8315932 | 0.79 | MEN1 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL11560889 | 0.79 | GRM5 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |