SCHEMBL7144807

SCHEMBL7144807

Nc1ccc(Oc2ccc(-c3ccc(N)cc3)cc2)cc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.82
TDP1 Q9NUW8 5/20 0.82
CYP3A4 P08684 3/20 0.82
TSHR P16473 1/20 0.82
MAOA P21397 2/20 0.67
TP53 P04637 1/20 0.65
MAPT P10636 5/20 0.64
TEAD4 Q15561 1/20 0.64
MAOB P27338 1/20 0.64
SMN1; SMN2 Q16637 3/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
POLB P06746 1/20 0.61
MITF O75030 1/20 0.61
GAA P10253 1/20 0.61
GFER P55789 1/20 0.61
NLRP1 Q9C000 1/20 0.61
NOD2 Q9HC29 1/20 0.61
NPC1 O15118 3/20 0.56
RAB9A P51151 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8827988 1.00 ALDH1A1 (0.82) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL1271568 1.00 ALDH1A1 (0.82) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL64458 1.00 ALDH1A1 (0.82) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL3482529 1.00 ALDH1A1 (0.82) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL12098596 1.00 ALDH1A1 (0.82) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL3482671 1.00 ALDH1A1 (0.82) ALDH1A1TDP1CYP3A4TSHRMAOA
Hydrochloric Acid SCHEMBL8642994 0.97 ALDH1A1 (0.78) ALDH1A1TDP1CYP3A4TSHRMAOA
Ammonia Solution, Strong SCHEMBL8013462 0.97 ALDH1A1 (0.78) ALDH1A1TDP1CYP3A4TSHRMAOA
Water SCHEMBL5479194 0.97 ALDH1A1 (0.78) ALDH1A1TDP1CYP3A4TSHRMAOA
Water SCHEMBL28256237 0.97 ALDH1A1 (0.78) ALDH1A1TDP1CYP3A4TSHRMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789577-B1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORP (US) 2003-03-12 EP disclosed
EP-0671928-B1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORP (US) 2002-11-27 EP disclosed
EP-1258492-A1 N-substituted oligomers and methods for their synthesis, e.g. polyglycine bearing nucleic acid bases CHIRON CORPORATION (US) 2002-11-20 EP disclosed
US-5977301-A AUTOMATED AND EFFICIENT SYNTHESIS BY REACTING SOLID SUPPORT BOUND AMINE WITH AN ACYLATING SUBMONOMER TO PRODUCE A SOLID SUPPORT-BOUND AMIDE WHICH CAN BE FURTHER REACTED; ONLY REACTIVE SIDE CHAINS NEED PROTECTED CHIRON CORPORATION (US) 1999-11-02 US disclosed
US-5877278-A SOLID PHASE SYNTHESIS USING TWO SUBMONOMERS-AN ACYLATING AGENT, E.G. A HALOACETIC ACID, AND A PRIMARY AMINE; CYCLIZATION TO PRODUCE MIMETICS OF DRUGS; ELIMINATION OF THE NECESSITY OF PROTECTION GROUPS CHIRON CORPORATION (US) 1999-03-02 US disclosed
US-5831005-A ACYLATION, NUCLEOPHILIC DISPLACEMENT CYCLES CHIRON CORPORATION (US) 1998-11-03 US disclosed
EP-0789577-A4 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORP (US) 1998-07-22 EP disclosed
EP-0789577-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1997-08-20 EP disclosed
EP-0671928-A4 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS. CHIRON CORP (US) 1997-04-23 EP disclosed
WO-1996040202-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1996-12-19 WO disclosed
EP-0411772-B1 Flexible printed-circuit base board and process for producing the same CHISSO CORP (JP) 1996-03-27 EP disclosed
US-5480871-A TREATMENT OF BENIGN PROSTATIC HYPERPLASIA CHIRON CORPORATION (US) 1996-01-02 US disclosed
EP-0671928-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1995-09-20 EP disclosed
US-5447916-A Hypotensive agents CHIRON CORPORATION (US) 1995-09-05 US disclosed
WO-1995004072-A1 PEPTOID ALPHA-1 ADRENERGIC RECEPTOR LIGANDS CHIRON CORPORATION (US) 1995-02-09 WO disclosed
WO-1994006451-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1994-03-31 WO disclosed
US-5112694-A Copper foil laminated with polyimidesiloxane copolymer CHISSO CORPORATION (JP) 1992-05-12 US disclosed
EP-0411772-A2 Flexible printed-circuit base board and process for producing the same Chisso Corporation (JP) 1991-02-06 EP disclosed