Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL8944188 | 0.96 | TSHR (0.77) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Tartaric Acid SCHEMBL30100371 | 0.96 | TSHR (0.77) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Cadaverine Tartrate SCHEMBL8933473 | 0.89 | TSHR (0.91) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Cadaverine Tartrate SCHEMBL17690 | 0.89 | TSHR (0.91) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Cadaverine Tartrate SCHEMBL981016 | 0.86 | TP53 (0.79) | TSHRTP53LMNANFKB1CYP2C19 | |
| Cadaverine Tartrate SCHEMBL7209361 | 0.86 | TSHR (0.71) | TSHRTP53LMNANFKB1CYP2C19 | |
| Cadaverine Tartrate SCHEMBL4778934 | 0.85 | TSHR (0.83) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Cadaverine Tartrate SCHEMBL8945831 | 0.85 | TSHR (0.83) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Cadaverine Tartrate SCHEMBL11578818 | 0.85 | TSHR (0.83) | TSHRTP53LMNAALDH1A1NFKB1 | |
| Cadaverine Tartrate SCHEMBL10430043 | 0.85 | TSHR (0.83) | TSHRTP53LMNAALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521445-B1 | Stereoselective ester hydrolysis of racemic trans-3-(4-methoxyphenyl) glycidic acid ester using a hydrolase enzyme; resolution; diltiazem production | SEPRACOR, INC. | 2003-02-18 | — | — | US | disclosed |
| EP-0657544-B1 | Process for preparing optically active glycidate esters | SEPRACOR INC (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0440723-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS | SEPRACOR INC (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0657544-A1 | Process for preparing optically active glycidate esters | SEPRACOR, INC. (US) | 1995-06-14 | — | — | EP | disclosed |
| US-5274300-A | Patent withdrawn after O.G. published | SEPRACOR, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0440723-A4 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS | — | 1992-05-20 | — | — | EP | disclosed |
| EP-0440723-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS. | SEPRACOR INC (US) | 1991-08-14 | — | — | EP | disclosed |
| WO-1990004643-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS | SEPRACOR, INC. (US) | 1990-05-03 | — | — | WO | disclosed |