Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186533 | 0.89 | GAA (0.53) | GAACNR1ALDH1A1LMNANAAA | |
| SCHEMBL622441 | 0.81 | — | — | |
| SCHEMBL2484600 | 0.80 | PHF8 (0.50) | GAACNR1ALDH1A1LMNACNR2 | |
| SCHEMBL8896628 | 0.79 | CNR1 (0.53) | CNR1ALDH1A1NAAACNR2MEN1 | |
| SCHEMBL4103969 | 0.79 | SELP (0.56) | CNR1ALDH1A1NAAACNR2MEN1 | |
| SCHEMBL8412393 | 0.78 | HDAC3 (0.52) | GAACNR1ALDH1A1LMNANAAA | |
| SCHEMBL1230303 | 0.78 | GAA (0.46) | GAACNR1ALDH1A1LMNANAAA | |
| SCHEMBL21706813 | 0.78 | GAA (0.55) | GAACNR1ALDH1A1LMNANAAA | |
| SCHEMBL14509608 | 0.78 | CNR1 (0.43) | GAACNR1ALDH1A1LMNANAAA | |
| SCHEMBL21505016 | 0.77 | CNR1 (0.46) | GAACNR1ALDH1A1LMNANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370527-A1 | INDOLONE DERIVATIVES HAVING VASCULAR-DAMAGING ACTIVITY | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002070478-A1 | INDOLONE DERIVATIVES HAVING VASCULAR-DAMAGING ACTIVITY | ASTRAZENECA AB (SE) | 2002-09-12 | — | — | WO | disclosed |