Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 4/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28573837 | 0.88 | SMN1; SMN2 (0.44) | HSP90AA1HSP90AB1LMNAALPLCXCR2 | |
| SCHEMBL31305450 | 0.85 | DPP4 (0.49) | LMNAGUSBCXCR2KMT2AMEN1 | |
| SCHEMBL3137641 | 0.85 | DPP4 (0.49) | LMNAGUSBCXCR2KMT2AMEN1 | |
| SCHEMBL3135986 | 0.85 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1LMNAGUSBALPL | |
| SCHEMBL31305456 | 0.85 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1LMNAGUSBALPL | |
| SCHEMBL7143281 | 0.85 | DPP4 (0.45) | HSP90AA1HSP90AB1GUSBCXCR2HSD11B1 | |
| SCHEMBL28402512 | 0.84 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1LMNAGUSBALPL | |
| SCHEMBL28406418 | 0.84 | GCGR (0.43) | HSP90AA1HSP90AB1LMNAALPLKMT2A | |
| SCHEMBL28406411 | 0.83 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1LMNAGUSBALPL | |
| SCHEMBL4269229 | 0.83 | MAPT (0.41) | HSP90AA1HSP90AB1LMNAALPLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515133-B1 | Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. | NEUROGEN CORPORATION | 2003-02-04 | — | — | US | disclosed |
| US-6121260-A | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives | NEUROGEN CORPORATION (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0996443-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2000-05-03 | — | — | EP | disclosed |
| WO-1999001128-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |