Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451175 | 0.84 | GPR119 (0.43) | GPR119HPGDRECQLEPHX1 | |
| SCHEMBL371712 | 0.81 | GPR119 (0.55) | GPR119KDM4EPKMHPGDRECQL | |
| SCHEMBL1186866 | 0.81 | KDM4E (0.50) | GPR119KDM4EPKMHPGDRECQL | |
| SCHEMBL310750 | 0.80 | GPR119 (0.57) | GPR119SCN9A | |
| SCHEMBL13597261 | 0.80 | HPGD (0.49) | GPR119KDM4EPKMHPGDRECQL | |
| SCHEMBL22849446 | 0.78 | HPGD (0.45) | GPR119KDM4EPKMHPGDRECQL | |
| SCHEMBL1295880 | 0.78 | GPR119 (0.64) | GPR119SCN9A | |
| SCHEMBL30288071 | 0.78 | GPR119 (0.56) | GPR119KDM4EPKMSCN9A | |
| SCHEMBL29190414 | 0.77 | GPR119 (0.54) | GPR119HPGDSCN9A | |
| SCHEMBL7556613 | 0.77 | GPR119 (0.51) | GPR119KDM4EPKMHPGDRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317432-A1 | PIPERIDINE DERIVATIVES FOR USE AS 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020483-A1 | PIPERIDINE DERIVATIVES FOR USE 2,3-OXIDOSQUALENE-LANOSTEROL CYCLASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-14 | — | — | WO | disclosed |