Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 18/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703597 | 1.00 | HDAC2 (0.42) | HDAC2HDAC1HDAC3CHRM3 | |
| SCHEMBL7145608 | 0.96 | HDAC2 (0.42) | HDAC2HDAC1HDAC3CHRM3 | |
| SCHEMBL7143284 | 0.89 | HDAC2 (0.40) | HDAC2HDAC1HDAC3CHRM3 | |
| SCHEMBL7703931 | 0.88 | ALDH1A1 (0.34) | HDAC2HDAC1CHRM3 | |
| SCHEMBL7139745 | 0.88 | ALDH1A1 (0.34) | HDAC2HDAC1CHRM3 | |
| SCHEMBL7142542 | 0.84 | ALDH1A1 (0.35) | HDAC2HDAC1HDAC3CHRM3 | |
| SCHEMBL7141349 | 0.79 | HDAC1 (0.45) | HDAC2HDAC1HDAC3CHRM3 | |
| SCHEMBL7143444 | 0.78 | KDM4D (0.35) | — | |
| SCHEMBL7144424 | 0.78 | CHRM3 (0.36) | CHRM3 | |
| SCHEMBL7143760 | 0.77 | HDAC2 (0.44) | HDAC2HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |