Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.79 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CA3 | P07451 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215463 | 0.88 | PTGS2 (1.00) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| Sulfamide SCHEMBL7139961 | 0.88 | PTGS1 (0.83) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| Sulfamide SCHEMBL7136410 | 0.87 | PTGS2 (0.78) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| Sulfamide SCHEMBL7135598 | 0.85 | PTGS2 (0.77) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| Sulfamide SCHEMBL7143150 | 0.84 | PTGS2 (0.78) | PTGS2PTGS1PDPK1CYP2C9CYP3A4 | |
| SCHEMBL4575824 | 0.84 | PDPK1 (0.90) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| Sulfamide SCHEMBL7135579 | 0.84 | PTGS2 (0.79) | PTGS2PTGS1PDPK1CYP2C9CYP3A4 | |
| SCHEMBL7113411 | 0.83 | PTGS2 (0.68) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL8290880 | 0.83 | PTGS2 (0.74) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL8765387 | 0.82 | PTGS2 (0.90) | PTGS2PTGS1PDPK1CYP2C9PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854723-B1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR USE IN VETERINARY THERAPIES AS ANTIINFLAMMATORY AGENTS | SEARLE & CO (US) | 2003-04-23 | — | — | EP | claimed |