Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867863 | 0.79 | MAPT (0.50) | KCNA5EPHX2ACHETP53SMN1; SMN2 | |
| SCHEMBL6866395 | 0.79 | KCNA5 (0.50) | KCNA5EPHX2ACHETP53SMN1; SMN2 | |
| SCHEMBL11443225 | 0.76 | KCNA5 (0.57) | KCNA5EPHX2ACHETP53SMN1; SMN2 | |
| SCHEMBL26473733 | 0.74 | EPHX2 (0.51) | KCNA5EPHX2TP53SMN1; SMN2MAPT | |
| SCHEMBL7409312 | 0.73 | ELANE (0.35) | LMNA | |
| SCHEMBL2768711 | 0.73 | KCNA5 (0.54) | KCNA5EPHX2ACHETP53SMN1; SMN2 | |
| SCHEMBL1760399 | 0.72 | KCNA5 (0.52) | KCNA5EPHX2ACHETP53SMN1; SMN2 | |
| SCHEMBL9828963 | 0.71 | KCNA5 (0.55) | KCNA5EPHX2ACHETP53SMN1; SMN2 | |
| SCHEMBL5344950 | 0.70 | LMNA (0.54) | ACHETP53SMN1; SMN2MAPTCA12 | |
| SCHEMBL3516609 | 0.70 | EPHX2 (0.51) | KCNA5EPHX2ACHETP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119571-B1 | TRICYCLIC DELTA3-PIPERIDINES AS ALPHA2-ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2003-02-19 | — | — | EP | disclosed |
| US-6495555-B1 | CENTRAL ALPHA2-ADRENOCEPTOR ANTAGONISTS; DEPRESSION; PARKINSON'S DISEASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-12-17 | — | — | US | disclosed |
| EP-1119571-A2 | TRICYCLIC DELTA3-PIPERIDINES AS ALPHA2-ANTAGONISTS | Janssen Pharmaceutica N.V. (BE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020421-A2 | TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-04-13 | — | — | WO | disclosed |