Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6745492 | 0.99 | HDAC6 (0.40) | HDAC6ICAM1THRBCLK1DYRK1A | |
| SCHEMBL7145313 | 0.87 | HDAC6 (0.37) | HDAC6ICAM1 | |
| SCHEMBL6749064 | 0.84 | HDAC6 (0.41) | HDAC6ICAM1THRB | |
| SCHEMBL6747454 | 0.84 | HDAC6 (0.43) | HDAC6ICAM1THRBCLK1DYRK1A | |
| SCHEMBL6745730 | 0.83 | HDAC6 (0.43) | HDAC6ICAM1THRB | |
| SCHEMBL6746519 | 0.82 | HDAC6 (0.40) | HDAC6ICAM1THRB | |
| SCHEMBL6747458 | 0.82 | HDAC6 (0.40) | HDAC6ICAM1THRBCLK1DYRK1A | |
| SCHEMBL6746539 | 0.82 | HDAC6 (0.41) | HDAC6ICAM1 | |
| SCHEMBL6747294 | 0.82 | HDAC6 (0.39) | HDAC6ICAM1 | |
| SCHEMBL6747276 | 0.82 | HDAC6 (0.42) | HDAC6ICAM1THRBCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |