Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145379 | 1.00 | MAPT (0.49) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7629636 | 0.90 | MAPT (0.48) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7629654 | 0.90 | MAPT (0.48) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7099399 | 0.89 | MAPT (0.50) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7103427 | 0.86 | MAPT (0.55) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7627970 | 0.86 | MAPT (0.52) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7190815 | 0.85 | MAPT (0.49) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7190819 | 0.85 | MAPT (0.49) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL6234634 | 0.84 | MMP13 (0.58) | MAPTMMP13KDM4EALDH1A1MEN1 | |
| SCHEMBL7629640 | 0.83 | MAPT (0.49) | MAPTMMP13KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |