SCHEMBL7145508

SCHEMBL7145508

O=C(O)CCNC(=O)CNC(=O)c1csc(NC(=O)NCc2ccccc2)n1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 12/20 0.53
ROCK1 Q13464 12/20 0.53
EGLN2 Q96KS0 1/20 0.44
EGLN1 Q9GZT9 1/20 0.44
HIF1A Q16665 1/20 0.43
MMP3 P08254 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
KDR P35968 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7145017 0.99 ROCK2 (0.52) ROCK2ROCK1EGLN2EGLN1HIF1A
SCHEMBL7141146 0.89 ROCK2 (0.59) ROCK2ROCK1HIF1AMMP3SMN1; SMN2
SCHEMBL7142027 0.87 PPID (0.48) ROCK2ROCK1HIF1ASMN1; SMN2
SCHEMBL18595025 0.87 ROCK2 (0.55) ROCK2ROCK1HIF1AMMP3SMN1; SMN2
Hydrochloric Acid SCHEMBL7992406 0.86 PPID (0.47) ROCK2ROCK1HIF1ASMN1; SMN2
SCHEMBL7140592 0.85 ROCK2 (0.53) ROCK2ROCK1MMP3SMN1; SMN2KDR
SCHEMBL7146616 0.85 ROCK2 (0.48) ROCK2ROCK1MMP3KDR
SCHEMBL7146622 0.85 ROCK2 (0.48) ROCK2ROCK1MMP3KDR
SCHEMBL7140468 0.84 ROCK2 (0.54) ROCK2ROCK1EGLN2EGLN1HIF1A
SCHEMBL7137153 0.84 ROCK2 (0.49) ROCK2ROCK1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0928790-B1 Thiazole derivatives HOFFMANN LA ROCHE (CH) 2003-03-05 EP disclosed
US-6344562-B1 ANTITUMOR AGENTS HOFFMANN-LA ROCHE INC. 2002-02-05 US disclosed
US-6320054-B1 INHIBIT BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES F CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. HOFFMAN-LA ROCHE INC. 2001-11-20 US disclosed
US-6100282-A Thiazole derivatives HOFFMAN-LA ROCHE INC. (US) 2000-08-08 US disclosed
EP-0928790-A1 Thiazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-07-14 EP disclosed