Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | GLA | P06280 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.59 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28318100 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL4281890 | 0.85 | KMT2A (0.58) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL23421423 | 0.85 | KMT2A (0.58) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL29631756 | 0.85 | KMT2A (0.58) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL22497413 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL31574332 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL9936012 | 0.81 | KMT2A (0.55) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL291405 | 0.81 | KMT2A (0.55) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL10579170 | 0.81 | KMT2A (0.55) | ALDH1A1KMT2AGLAHPGDKDM4E | |
| SCHEMBL29562242 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AGLAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369417-A1 | Acridine derivatives | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| EP-0970949-A1 | Acridine derivatives | Grünenthal GmbH (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-4866073-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1989-09-12 | — | — | US | disclosed |